Association Between Adherence to CPAP and Quality of Life-A Longitudinal Analysis

multiple imputation
linear mixed-effects
model comparison


  • We explored the effect of CPAP adherence on quality of life and other functional outcomes, as measured by the FOSQ global score, for the first 3 months of therapy.

  • The methods, which are summarized below included comparing a GEE to a linear mixed effects model, testing covariance structures, and choosing random effects structure

  • Based on our linear mixed effects model, we conclude that CPAP use is associated with improvement in FOSQ global score by 0.30 per hour increase in sleep (95% CI: 0.22, 0.38; t- value 7.5; p < 0.001). The interaction of time and CPAP use decreases FOSQ by -0.07 per hour sleep * month (95% CI: -0.11, -0.02; t-value = 3.0, p = 0.003). This may indicate a stronger effect of CPAP adherence early in therapy which wanes with time. Depression had the biggest effect in the model and decreased global FOSQ scores by -2.06 (95% CI: -2.90, -1.23; t-value - 4.8; p <0.001).